Development of an in vivo RNAi protocol to investigate gene function in the filarial nematode, Brugia malayi.
Our ability to control diseases caused by parasitic nematodes is constrained by a limited portfolio of effective drugs and a paucity of robust tools to here investigate parasitic nematode biology.RNA interference (RNAi) is a reverse-genetics tool with great potential to identify novel drug targets and interrogate parasite gene function, but present